File Name: lab on a chip technology fabrication and microfluidics .zip
Lab-on-a-chip LOC devices integrate and scale down laboratory functions and processes to a miniaturized chip format. Many LOC devices are used in a wide array of biomedical and other analytical applications including rapid pathogen detection, clinical diagnosis, forensic science, electrophoresis, flow cytometry, blood chemistry analysis, protein and DNA analysis. LOC devices can be fabricated from many types of material including various polymers, glass, or silicon, or combinations of these materials.
Microfluidics refers to the behaviour, precise control, and manipulation of fluids that are geometrically constrained to a small scale typically sub-millimeter at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering , physics , chemistry , biochemistry , nanotechnology , and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing , automation, and high-throughput screening.
The extremely high peak intensity associated with ultrashort pulse width of femtosecond laser allows us to induce nonlinear interaction such as multiphoton absorption and tunneling ionization with materials that are transparent to the laser wavelength. More importantly, focusing the femtosecond laser beam inside the transparent materials confines the nonlinear interaction only within the focal volume, enabling three-dimensional 3D micro- and nanofabrication. This 3D capability offers three different schemes, which involve undeformative, subtractive, and additive processing. The undeformative processing preforms internal refractive index modification to construct optical microcomponents including optical waveguides. Subtractive processing can realize the direct fabrication of 3D microfluidics, micromechanics, microelectronics, and photonic microcomponents in glass. Additive processing represented by two-photon polymerization enables the fabrication of 3D polymer micro- and nanostructures for photonic and microfluidic devices.
Springer Handbook of Nanotechnology pp Cite as. Various microfluidic components and their characteristics, along with the demonstration of two recent achievements of lab-on-a-chip systems have been reviewed and discussed. Many microfluidic devices and components have been developed during the past few decades, as introduced earlier for various applications. The design and development of microfluidic devices still depend on the specific purposes of the devices actuation or sensing due to a wide variety of application areas, which encourages researchers to develop novel, purpose-specific microfluidic devices and systems. Microfluidics is the real multidisciplinary research field that requires basic knowledge in fluidics, micromachining, electromagnetics, materials, and chemistry for better applications. Among the various application areas of microfluidics, one of the most important application areas is the lab-on-a-chip system. Lab-on-a-chip is becoming a revolutionary tool for many different applications in chemical and biological analyses due to its fascinating advantages fast and low cost over conventional chemical or biological laboratories.
The concept is based on the combination of multimaterial direct-ink-writing method and an extrusion-based 3D printing pilot line, in order to fabricate microstructured detection devices with the ability to perform all steps of chemical analysis in an automated fashion. The functionality of these devices will be evaluated based on their ability to streamline all steps needed to obtain mobility and binding-based identity information in one continuous biochemical detection system. Optimum in-line control systems will be incorporated in various stages of the fabrication process, to achieve precise control and repeatability. Microfluidic MEMS are increasingly recognized as a unique technology field for the development of biomedical devices BioMEMS , due to their functional performance on the microscale, at the dimensions of which most physiological processes are operative. Applications near micro- and nanoscale are promising in the field of intelligent biosensors, where it enables the monolithic integration of sensing devices with intelligent functions like molecular detection, signal analysis, electrical stimulation, data transmission, etc.
These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. This article is part of the Fundamental and Applied Reviews in Analytical Chemistry special issue.
advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip.
Bach, Lam D. Tran, Ha H. The working parts of the micro-valve and microfluidic channel were fabricated from Poly dimethyl siloxane materials. The study on controlling liquid flows proved that this valve system was effective for the experiments on the flow mixing and delivering the reactants into the micro-reaction chamber in order.
Панк кивнул. - Tenia el anillo. Он получил кольцо.
Мы выделили отдаваемые им команды - смотрите. Смотрите, на что он нацелен. Шеф систем безопасности прочитал текст и схватился за поручень. - О Боже, - прошептал. - Ну и мерзавец этот Танкадо.
Thank you for visiting nature.