File Name: drug like properties concepts structure design and methods .zip
Drug-like properties, such as as solubility, permeability, and metabolism, are examined as the fundamental determinants of how drugs behave in vivo. The concepts of pharmacokinetics are discussed with a minimum of mathematical equations, placing emphasis on their practical applications to drug discovery projects. Everyday low prices and free delivery on eligible orders. Kerns, E. Academic Press, Amsterdam, Kerns A copy that has been read, but remains in excellent condition. Pages are intact and are not marred by notes or highlighting, but may contain a neat previous owner name.
Lieferung innerhalb Deutschlands versandkostenfrei. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME absorption, distribution, metabolism, elimination properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation.
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If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening high throughput , diagnosis medium throughput and in-depth low throughput analysis of drug properties.
This review gives an overview of computer-based molecular de novo design methods on a conceptual level. We focus on the design of small, drug-like molecules. There are also attempts in the design. September 17, Amsterdam: Academic Press.
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Request PDF | Drug-Like Properties: Concepts, Structure Design and Methods | Of the thousands of novel compounds that a drug discovery project team invents.Elinda P. 16.05.2021 at 12:22
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME absorption, distribution, metabolism, elimination properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials.Centtimentu 17.05.2021 at 16:06
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