File Name: difference between osteoarthritis and rheumatoid arthritis .zip
Discrimination of rheumatoid arthritis RA patients from patients with other inflammatory or degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discrimination by employing a novel unbiased approach using rule-based classifiers.
Arthritis is a broad term for joint inflammation, but there are many kinds, starting with the two most common: osteoarthritis OA and rheumatoid arthritis RA. Learn more about how to tell these two chronic conditions apart. OA is the breakdown of a joint, says Bill Robinson, M. It starts when the cartilage—the elastic slippery material that protects the ends of the bones in a joint from rubbing together—begins to thin.
Changes in the cartilage can affect the whole joint, triggering inflammation in the synovial membrane the lining surrounding the joint and surrounding tissue, says Dr. Eventually, the cartilage may wear completely away, and bone rubs against bone. RA is an autoimmune disease in which the immune system misfires and targets the synovial membrane, attacking it as if fighting off an infection, says Dalit Ashany, M.
As a result, the synovial membrane becomes thickened and inflamed—much more inflamed than it would get with OA, notes Dr.
If you experienced any trauma or injury to a joint when you were younger, it can develop OA years later, says Dr. But the most common joints affected are the weight-bearing joints of the knees, hips, and spine, plus the hands—usually the fingertip joint or middle finger joint, or the base of the thumb. In the hips and knees, OA is usually asymmetrical, affecting one side or the other, says Ali Askari, M. RA starts most often in the small joints of the hands or feet, and later spreads to larger joints like knees, ankles, elbows, hips, shoulders, or the neck.
In the hands, RA may target the wrist or finger knuckles the bottom and middle knuckles, not the top joint. In the feet, it often occurs in the joints connecting feet to toes. Meanwhile, RA never involves the spine, except for the cervical spine the neck , he adds.
With OA, disintegration of cartilage triggers the release of chemicals that cause pain, says Dr. Askari, but usually not much redness, warmth, or swelling. Many OA patients also experience joint stiffness after waking up in the morning, or after sitting for prolonged periods, but that usually fades within 30 minutes, says Dr. Because RA affects the immune system, inflammation levels are much higher compared with OA, she says.
And because RA is a systemic disease inflammatory mediators are released into the blood and can travel throughout the body , many people with RA also experience fatigue and general malaise, says Dr.
Bones react to the damage of OA by releasing cells called osteoblasts, responsible for the formation of new bone, says Dr. This may eventually lead to bony protrusions—or osteophytes. RA, on the other hand, is marked by the presence of osteoclasts, cells that cause bone erosion, says Dr.
Severe or untreated RA can cause bones to wear away and joints to shift, leading to permanent deformities over time. Still, this typically only happens in severe or untreated RA—and can be prevented through early diagnosis and proper treatment.
Both OA and RA require you to give a medical history and undergo a clinical exam for diagnosis. But for diagnosing OA, X-rays are also important, says Dr. X-ray images can show if the space between the bones is becoming narrower, a sign of cartilage loss. And they can reveal the presence of those bony growths called osteophytes. Magnetic resonance imaging MRI may also be used to detect more detailed changes in the cartilage and surrounding tissues, says Dr.
Several lab tests are useful for confirming RA, says Dr. Other tests can measure the inflammatory markers in the blood and in the synovial fluid of the affected joint—the higher the inflammatory cell counts, the more likely it is to be RA or another inflammatory disease.
By strengthening the muscles surrounding the joint, more stress gets distributed onto those muscles, and less of it lands on the joint, says Dr. To manage the pain, acetaminophen Tylenol or nonsteroidal anti-inflammatory drugs ibuprofen can help. And for severe pain, steroid or hyaluronic acid injections may help, Dr.
Kim says. While OA meds can only treat symptoms, RA meds can actually slow the progression of the disease—even put it into remission—by tamping down on the overactive immune system, says Dr. RA treatment usually starts with disease-modifying anti-rheumatic drugs DMARDs —the most common is methotrexate—which work by interfering with pathways in the immune system that lead to inflammation. Hand OA: Arthritis Foundation. Jerilyn Covert is a writer, editor, and copy editor with 15 years of publishing experience.
She shares their insights and advice so others can use them to improve their lives. What can we help you find? Rheumatoid Arthritis RA Causes. Osteoarthritis or Rheumatoid Arthritis? June 24, Medically Reviewed by. RA Is a Systemic Disease. Wikipedia Commons. OA Creates Bone. RA Erodes Bone. Start Survey.
Correlation of fatigue with pain and disability in rheumatoid arthritis and osteoarthritis, respectively. Correspondence to. The degree of fatigue was evaluated with a visual analogue scale and the Multidimensional Assessment of Fatigue. Pain was evaluated with a visual analogue scale as well as Patient Global Assessment. For disability evaluation, the Health Assessment Questionnaire was performed. Age, gender, disease duration, education, income, antirheumatic drugs used and comorbidity were also obtained. The significance level was 0.
Several studies have demonstrated differences between ethnic groups in the severity and pattern of rheumatoid arthritis RA and osteoarthritis OA. There were 88 RA patients in each setting, matched for age, gender and disease duration. The pattern of OA was sought by recording the details of 44 consecutive new referrals to each clinic. Amongst the RA patients, joint deformity and tenderness were similar, but disability was more severe, ESR higher, anaemia more pronounced and RA latex more often positive amongst the Pakistani patients.
Osteoarthritis OA is the most common type of arthritis. Rheumatoid arthritis RA is recognized as the most disabling type of arthritis. While they both fall under the "arthritis" umbrella and share certain similarities, these diseases have significant differences. More than 30 million people in the United States are believed to have osteoarthritis, which is a degenerative joint disease. It's often called wear-and-tear arthritis and is caused by the breakdown of joint cartilage—cushioning that sits between the bones that form your joints.
Erosive OA EOA shows increased synovial thickening, rarely associated with PD features never found in patients with non-inflammatory joint pain. We compared the joint score of the hand including wrist, MCP and PIP joints with smaller, predefined joint scores, including 20, 18, 16, 14 and 10 and two sets of 4-joint for RA and scoring systems comprising 20, 12, 10 and 4 joints for OA. Results: In the joint system, OA patients [mean age When comparing OA joint scores, the joint score was the most comprehensive in assessing changes compared with the scores from 12, 10 or 4 joints. Interestingly, some OA joints were also characterized by inflammatory changes. The effectiveness of using smaller joint scores in RA may benefit time-constrained clinical settings.
Erosive OA EOA shows increased synovial thickening, rarely associated with PD features never found in patients with non-inflammatory joint pain. We compared the joint score of the hand including wrist, MCP and PIP joints with smaller, predefined joint scores, including 20, 18, 16, 14 and 10 and two sets of 4-joint for RA and scoring systems comprising 20, 12, 10 and 4 joints for OA. Results: In the joint system, OA patients [mean age When comparing OA joint scores, the joint score was the most comprehensive in assessing changes compared with the scores from 12, 10 or 4 joints.
Arthritis is a broad term for joint inflammation, but there are many kinds, starting with the two most common: osteoarthritis OA and rheumatoid arthritis RA. Learn more about how to tell these two chronic conditions apart. OA is the breakdown of a joint, says Bill Robinson, M.
If opening jars becomes more difficult because of painful hands, or if climbing stairs produces pain in your knees, "arthritis" is often the first thing that comes to mind. The two most common forms of arthritis—osteoarthritis and rheumatoid arthritis—can cause similar aches and pains, but there are a few key differences between them. For example:.
Rheumatoid arthritis and osteoarthritis both cause joint pain and stiffness. They are both forms of arthritis but have different causes and treatments.