drug excipient interactions and incompatibilities pdf Tuesday, May 11, 2021 6:26:32 PM

Drug Excipient Interactions And Incompatibilities Pdf

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Drug-excipient compatibility studies represent an important phase in drug development.

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The results show that two multivariate techniques, principal component analysis PCA and cluster analysis CA , can be successfully used for interpretation of TG traces, while the TG is used alone as a screening technique to assess compatibility. The results obtained by using TG analysis, supported by PCA and CA, were approved by those of differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction. Preformulation stage of solid dosage formulations includes detection of possible interactions of an active pharmaceutical ingredient API with excipients [ 1 — 4 ].

Drug-excipient interaction and its importance in dosage form development

Abstract: Estriol , is a major urinary estrogen hormone. In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate. Publication Date : September 30, Year , Volume 3 , Issue 2, Pages -

Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review Published on Jan 1, in Journal of Excipients and Food Chemicals. Sonali S. Bharate 15 Estimated H-index: View Paper. Add to Collection.

Scientific Research An Academic Publisher. Excipients are included in dosage forms to aid manufacture, administration or absorption. Excipients can initiate, propagate or participate in chemical or physical interactions with an active, possibly leading to compromised quality or performance of the medication. Chemical interaction can lead to degradation of the active ingredient, theory by reducing the amount available for the therapeutic effect; reaction products may compromise safety or tolerance. Physical interactions can affect the rate of dissolution, uniformity of dose or ease of administration. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and their interaction with actives as well as with each other is the important phenomenon in the drug excipient interaction process [1] -[3]. Excipients may have functional groups that interact directly with active pharmaceutical ingredients.

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To facilitate the development of novel drug delivery systems, the demand of new excipients has been increased. Excipients is selected and used because it contributes one or more functional attributes to the product characteristics. The quality of medicines depends not only on the active principles and production processes, but also on the performance of the excipients. In earlier days, excipient s were considered inactive ingredients, but they may have tremendous effect on performance of active pharmaceutical ingredients in dosage form. The magnitude of this effect will depend upon physicochemical properties of drugs as well as quantity and quality of excipients used. Dibrugarh- Assam. Sign In.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Anitha and V. Rao and T. Mamatha and J. Rao Published Chemistry. Excipients are included in dosage forms to aid manufacture, administration or absorption.


PDF | Studies of active drug/excipient compatibility represent an important of interaction and incompatibilities of commonly used pharmaceutical excipients.


Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets

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4 Comments

Romano P. 12.05.2021 at 16:21

drug and excipients will potentially affect the product stability and bioavailability. Incompatibility occurring due to complexation of a drug with.

Azura S. 15.05.2021 at 03:50

Thank you for visiting nature.

Upovunam 15.05.2021 at 09:13

Abstract: Estriol , is a major urinary estrogen hormone.

Cinty V. 16.05.2021 at 06:30

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