File Name: polymorphisms of dna repair genes xrcc1 and lig4 and idiopathic male infertility .zip
This is an open access article distributed under the terms of Creative Commons Attribution License. Polycyclic aromatic hydrocarbons PAHs are considered a dangerous pollutant for human health due to their carcinogenic and mutagenic activity. PAHs are generated by the incomplete combustion of fossil fuels, tobacco smoke and grilled or broiled foods 1 — 3. Biomarkers are required to develop novel therapeutics and risk-assessment methodologies.
One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high levels of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair BER pathway, 8-oxoguanine glycosylase 1 OGG1. The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins APE1, XRCC1 needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body.
Metrics details. The mismatch repair MMR pathway plays an important role in the maintenance of the genome integrity, meiotic recombination and gametogenesis. This study investigated whether genetic variations in MMR genes are associated with an increased risk of sperm DNA damage and male infertility. Fluorescence resonance energy transfer FRET and co-immunoprecipitation techniques were employed to determine the effects of functional variants. Meanwhile, we also identified a possible contribution of PMS2 rs to the risk of male infertility with normal sperm count. Our results provide evidence supporting the involvement of genetic polymorphisms in MMR genes in the aetiology of male infertility. Peer Review reports.
Initiating events frequency determination. The main focus was on events occurring during most recent operating history i. The final IE frequencies were estimated by incorporating both NPS experience and nuclear industry experience. For those IE groups with few or no NPS events, the final estimate was made by means of a Bayesian update with general nuclear industry values. Exceptions are rare loss-of-coolant-accidents LOCA events, where evaluation of engineering aspects is used in order to determine frequency. Determination of the frequency of polymorphisms in genes related to the genome stability maintenance of the population residing at Monte Alegre, PA Brazil municipality.
X-ray repair cross-complementing group 1 XRCC1 single nucleotide polymorphisms SNPs might correlate with male infertility susceptibility. This association has been described; however, the findings remain inconsistent. Consequently, this meta-analysis was conducted to characterize the relationship between XRCC1 SNPs and male infertility susceptibility.
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Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to.Tripfesichtsleev 21.05.2021 at 17:59
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